Cognitive Decline in Prodromal Alzheimer Disease and Mild Cognitive Impairment
نویسندگان
چکیده
منابع مشابه
Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment.
OBJECTIVE To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease. DESIGN Longitudinal cohort study with up to 16 years of observation. PARTICIPANTS Older persons from 2 studies underwent annual clinical evaluations that included cognitive function testing and clinical classification of mild cognitive impairment, dementia, and Alzheimer disease. At ba...
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Mild cognitive impairment (MCI) is a syndrome which, depending on various neurobiological, psychological and social factors, carries a high risk of developing into dementia. As far as diagnostic uncertainty and the heterogeneous underlying pathophysiological mechanisms are concerned, only limited therapeutic options are currently available. Clinical trials involving a wide range of substances h...
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Introduction: Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. Methods: In this study, the thresholds of...
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OBJECTIVES While plasma biomarkers have been proposed to aid in the clinical diagnosis of Alzheimer disease (AD), few biomarkers have been validated in independent patient cohorts. Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI). METHODS Using a targeted prote...
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BACKGROUND Immunoreactivity for several chemokines and for their related receptors has been demonstrated in resident cells of the central nervous system, and the up-regulation of some of them is associated with pathological changes found in Alzheimer disease (AD). OBJECTIVE To determine interferon-gamma-inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), and interleukin 8 (I...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2011
ISSN: 0003-9942
DOI: 10.1001/archneurol.2011.31